Jens Juul Holst Selected Research

gastric inhibitory polypeptide receptor

1/2022	Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.
1/2021	What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
1/2021	GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.
12/2020	Incretin Hormones and Type 2 Diabetes-Mechanistic Insights and Therapeutic Approaches.
1/2020	Recent advances of GIP and future horizons.
1/2020	GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists.
1/2019	Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.
4/2016	Searching for the physiological role of glucose-dependent insulinotropic polypeptide.
12/2011	Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.
7/2002	Inhibition of gastric inhibitory polypeptide signaling prevents obesity.

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Jens Juul Holst Research Topics

Disease

76	Type 2 Diabetes Mellitus (MODY) 11/2022 - 03/2002
47	Insulin Resistance 03/2022 - 03/2002
40	Obesity 05/2022 - 07/2002
26	Weight Loss (Weight Reduction) 01/2022 - 11/2007
22	Body Weight (Weight, Body) 01/2022 - 05/2002
21	Overweight 03/2022 - 11/2007
21	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 10/2007
18	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 11/2008
14	Bone Resorption 01/2022 - 01/2004
7	Hyperglycemia 01/2017 - 10/2006
6	Inflammation (Inflammations) 01/2021 - 11/2013
6	Neoplasms (Cancer) 01/2021 - 09/2007
6	Hyperinsulinism (Hyperinsulinemia) 03/2020 - 09/2010
5	Glucose Intolerance 11/2022 - 10/2005
5	Weight Gain 01/2022 - 03/2014
5	Short Bowel Syndrome 04/2021 - 06/2011
4	Hyperlipidemias (Hyperlipidemia) 01/2021 - 01/2004
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 03/2018
4	Mucositis 01/2019 - 07/2012
3	Birth Weight (Birth Weights) 01/2020 - 08/2005
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 12/2004
3	Nausea 03/2016 - 06/2014
3	Prediabetic State (Prediabetes) 07/2015 - 03/2013
3	Myocardial Infarction 06/2012 - 01/2004
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2021 - 08/2010
2	Adenoma (Adenomas) 01/2021 - 11/2012
2	Osteoporosis 01/2021 - 01/2019
2	Fibrosis (Cirrhosis) 11/2020 - 03/2009
2	Vomiting 02/2019 - 03/2016
2	Dyslipidemias (Dyslipidemia) 01/2018 - 07/2015

Drug/Important Bio-Agent (IBA)

78	Glucose (Dextrose)FDA LinkGeneric 11/2022 - 03/2002
73	Glucagon-Like Peptide 1 (GLP 1)IBA 11/2022 - 03/2002
50	Hormones (Hormone)IBA 05/2022 - 11/2002
40	Insulin (Novolin)FDA Link 01/2021 - 03/2002
29	IncretinsIBA 03/2022 - 08/2004
28	Glucagon (Glukagon)FDA Link 01/2022 - 03/2002
26	Peptides (Polypeptides)IBA 01/2022 - 11/2002
13	Liraglutide FDA Link 11/2019 - 11/2012
10	gastric inhibitory polypeptide receptorIBA 01/2022 - 07/2002
10	Glucagon-Like Peptide-1 Receptor AgonistsIBA 12/2020 - 10/2007
9	Glucagon-Like Peptide-1 ReceptorIBA 01/2021 - 05/2004
8	CarbohydratesIBA 01/2022 - 04/2003
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2013
8	LipidsIBA 01/2021 - 01/2011
7	Triglycerides (Triacylglycerol)IBA 06/2019 - 01/2004
6	GhrelinIBA 01/2020 - 02/2008
5	Proglucagon (Glucagon Precursors)IBA 01/2022 - 06/2005
5	Hypoglycemic Agents (Hypoglycemics)IBA 01/2022 - 11/2008
5	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 01/2022 - 01/2015
5	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 08/2015 - 12/2004
5	Bile Acids and Salts (Bile Acids)IBA 07/2015 - 03/2010
5	Nonesterified Fatty Acids (NEFA)IBA 12/2013 - 03/2002
4	Glucagon Receptors (Glucagon Receptor)IBA 01/2022 - 12/2015
4	Collagen Type I (Type I Collagen)IBA 11/2021 - 01/2004
4	EnzymesIBA 01/2021 - 08/2010
4	Peptide YYIBA 01/2021 - 02/2015
4	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 09/2019 - 07/2002
4	Dipeptidyl-Peptidase IV InhibitorsIBA 11/2017 - 01/2003
4	Metformin (Glucophage)FDA LinkGeneric 05/2017 - 05/2009
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2019
3	CollagenIBA 01/2022 - 01/2019
3	Whey ProteinsIBA 01/2021 - 01/2018
3	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2021 - 02/2008
3	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2021 - 01/2015
3	Sitagliptin Phosphate (Januvia)FDA Link 01/2021 - 11/2012
3	C-PeptideIBA 03/2020 - 03/2002
3	ProcollagenIBA 01/2020 - 01/2019
3	Exenatide (Byetta)FDA Link 02/2019 - 06/2012
3	Interleukin-6 (Interleukin 6)IBA 01/2019 - 11/2013
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2019 - 01/2012
3	Colesevelam Hydrochloride (Welchol)FDA Link 01/2012 - 03/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2014
2	Procollagen Type IIBA 01/2022 - 01/2021
2	Dietary Fiber FDA Link 01/2021 - 01/2019
2	Growth Hormone (Somatotropin)IBA 01/2021 - 11/2012
2	GlicentinIBA 11/2020 - 01/2020
2	Amino Acids FDA Link 11/2020 - 01/2018
2	OxyntomodulinIBA 01/2020 - 12/2015
2	Atrial Natriuretic Factor (ANF)IBA 01/2020 - 04/2016
2	C-Reactive ProteinIBA 01/2019 - 01/2019
2	LeptinIBA 01/2019 - 10/2003
2	Glycerol (Glycerine)FDA LinkGeneric 12/2018 - 12/2013
2	Resistant StarchIBA 03/2018 - 10/2015
2	oxidized low density lipoproteinIBA 03/2018 - 07/2015
2	Peroxidase (Myeloperoxidase)IBA 01/2018 - 07/2012
2	teduglutideIBA 01/2018 - 02/2012

Therapy/Procedure

22	Therapeutics 01/2022 - 11/2002
18	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2022 - 12/2013
10	Bariatric Surgery 11/2020 - 12/2013
6	Drug Therapy (Chemotherapy) 01/2022 - 07/2012
6	Gastrectomy 01/2022 - 01/2014
4	Glycemic Control 01/2020 - 01/2014
3	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 09/2020 - 01/2017
3	Caloric Restriction 11/2019 - 02/2015
3	Enteral Nutrition (Feeding, Tube) 01/2016 - 11/2005
3	Subcutaneous Infusions 12/2004 - 03/2002
2	High-Protein Diet 01/2022 - 09/2020
2	Paleolithic Diet 09/2021 - 06/2019
2	Jejunostomy 01/2021 - 01/2018
2	Transplantation 01/2019 - 11/2013